The effects of electroacupuncture on the expression of insulin like growth factor 1 in the hippocampal CA1 region after ischemia-reperfusion / 中华物理医学与康复杂志
Chinese Journal of Physical Medicine and Rehabilitation
;
(12)2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-682852
ABSTRACT
Objective To investigate the effects of electroacupuncture on cell apoptosis(CA)and the ex- pression of insulin like growth factor 1(IGF_1)in the hippocampal CA1 region of rats'brains after cerebral ischemic- reperfusion(CIR).Methods Middle cerebral artery obturation(MCAO)was established by the suture embolic method.CA and the expression of IGF_1 in the hippocampal CA1 region were detected by immunohistochemical meth- ods and TUNEL staining,respectively.Results Compared with those in the normal and sham operation groups, apoptotic cells were significantly increased in the hippocampal CA1 region of the model group(P<0.01),while the expression of IGF_1 was slightly enhanced and plasma staining was also slightly positive(P<0.05).Apoptotic cells in the CA1 region in the electroacupuncture group were obviously fewer in comparison with the normal group(P<0.01),while the expression of IGF_1 was distinctly increased and the plasma staining was also obviously positive(P<0.01).Conclusion Electroacupuncture treatment has preventive and therapeutic effects on ischemia-reperfusion injury,and its mechanism might be related with up-regulating the expression of IGF_1 and inhibiting CA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of Physical Medicine and Rehabilitation
Ano de publicação:
2003
Tipo de documento:
Artigo
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