The relationship between acid reflux and noncardiac chest pain / 中华消化杂志

ABSTRACT

Objective To characterize the clinical presentation of noncardiac chest pain(NCCP), to investigate the quality of life among NCCP patients,and to understand the relation between NCCP and acid reflux and the value of proton pump inhibitor(PPI) in diagnosis of NCCP.Methods Eighty-seven NCCP patients were enrolled to the study.All patients received lansoprzole 30 mg twice daily for 7 days. Patients filled out a questionnaire survey before and after the PPI treatment.The questionnaire included the general personal data,the symptom scale,the medical outcome study 36-item short form healthy survey(SF-36),Zung Self Rating Anxiety Scale(SAS) and Zung Self-rating Depression Scale(SDS).The results were analyzed in comparisons of healthy control group.Results①The most common cause for NCCP was gastroesophageal reflux disease (GERD).The typical reflux syndrome presented among 34.5% of the patients.②Among 87 patients,acid-related NCCP was accounted for 56.3% (49/87), whereas non-acid-related NCCP was accounted for 43.7% (38/87).The sensitivity and specificity of PPI test were 91% and 81%,respectively.③Except the role of role emotional(RE),7 healthy conceptions in the health-related quality of life in NCCP patients were significantly lower than those in healthy volun- teers(P