Apoptosis and Expression of AQP5 and TGF-beta in the Irradiated Rat Submandibular Gland / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 145-154, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-68320
ABSTRACT
PURPOSE:
To evaluate the effect of X-ray irradiation on apoptosis and change of expression of aquaporin 5 (AQP5) and transforming growth factor-beta(TGF-beta) in the rat submandibular gland (SMG). MATERIALS ANDMETHODS:
SMGs of 120 male Sprague-Dawley rats were irradiated with a single X-ray dose (3, 10, 20, or 30 Gy). At the early and late post-irradiation phase, apoptosis was measured by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method, and expression of AQP5 and TGF-beta was determined by immunohistochemical staining.RESULTS:
At the late post-irradiation phase, increased apoptosis was evident and marked decreases of expression of AQP5 expression by acinar cells and TGF-beta expression by ductal cells were evident.CONCLUSION:
Apoptosis after X-ray irradiation develops relatively late in rat SMG. Irradiation reduces AQP5 and TGF-beta expression in different SMG cell types.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glândula Submandibular
/
Fator de Crescimento Transformador beta
/
Ratos Sprague-Dawley
/
Apoptose
/
DNA Nucleotidilexotransferase
/
Aquaporina 5
/
Células Acinares
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2009
Tipo de documento:
Artigo
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