The of relationship between GABA,GAD and gastric cancer / 医学研究生学报

ABSTRACT

aminobutyric acid(GABA) is a principal inhibitory neurotransmitter in the mammalian central nervous system(CNS). In recent years,some studies have demonstrated that GABA is also present in various peripheral tissues,including the gastrointestinal tract. GABA acts as a gut hormone in addition to its role as an enteric neurotransmitter,which involves in the transport and regulation of intracellular information in stomach. Therefore,it inhabits development and growth of gastric cancer. Glutamic acid decarboxylase(GAD) is a major GABA synthesizing enzyme. This review will narrate the relationship between GABA,GAD and gastric cancer.