Gadobenate Dimeglumine-enhanced MR of VX2 Carcinoma in Rabbit Liver: Usefulness of the Delayed Phase Imaging and Optimal Pulse Sequence
Journal of the Korean Radiological Society
;
: 51-59, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-68443
ABSTRACT
PURPOSE:
To assess the diagnostic value of delayed imaging using gadobenate dimeglumine(MultiHance) and to determine the optimal pulse sequence for the detection of VX2 carcinoma lesions in the rabbit. MATERIALS ANDMETHODS:
Twelve VX2 carcinomas implanted in the livers of eleven New Zealand rabbits were studied. All patients underwent an MR protocol consisting of precontrast T2-and T1-weighted sequences, followed by repetition of the T1-weighted sequence at 0 to 30 (arterial phase), 31-60 (portal phase), and 40 minutes (delayed phase) after the intravenous administration of 0.1 mmol/kg of gadobenate dimeglumine. The signal-to-noise ratio (SNR) of the liver and VX2 tumor, and the lesion-to-liver contrast-to-noise ratio (CNR) of precontrast and postcontrast MR images were quantitativlely analyzed, and two experienced radiologists evaluated image quality in terms of lesion conspicuity, artifact, mass delineation, and vascular anatomy.RESULTS:
Liver SNR was significantly higher at delayed imaging than at precontrast, arterial, and portal imaging (p<0.05), while lesion SNR was significantly higher at delayed imaging than at precontrast imaging (p<0.05). Lesion CNR was higher at delayed imaging than at precontrast and portal phase imaging (p<0.05), but there was no difference between arterial and delayed imaging. The latter provided better mass delineation than precontrast, arterial and portal phase imaging (p<0.05). While in terms of lesion conspicuity and vascular anatomy, the delayed phase was better than the arterial phase (p<0.05) but similar to the precontrast and portal phase. During the delayed phase, the gradient-echo sequence showed better results than the spin-echo in terms of liver SNR, and lesion SNR and CNR (p<0.05).CONCLUSION:
Because it provides better lesion conspicuity and mass delineation by improving liver SNR and lesion-to-liver CNR, the addition of the delayed phase to a dynamic MRI sequence after gadobenate dimeglumine administration facilitates lesion detection. For delayed-phase imaging, the gradient-echo sequence is superior to the spin-echo sequence.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imageamento por Ressonância Magnética
/
Artefatos
/
Razão Sinal-Ruído
/
Administração Intravenosa
/
Fígado
/
Neoplasias Hepáticas
Tipo de estudo:
Guia de Prática Clínica
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Radiological Society
Ano de publicação:
2002
Tipo de documento:
Artigo
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