Multiple High-affinity Iron-uptake Systems of Vibrio vulnificus
Journal of Bacteriology and Virology
;
: 168-176, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-68538
ABSTRACT
Vibrio vulnificus is a Gram-negative halophilic bacterium that causes necrotizing wound infections and fatal septicemia, which mainly occur in patients with elevated serum or tissue iron levels. Accumulated experimental data clearly show that V. vulnificus is a ferrophilic bacterium that requires more available iron for growth than other pathogenic bacteria, has multiple iron-uptake systems, which play important roles in the pathogenesis of the V. vulnificus infections. This review summarized the composition, regulation and significance of V. vulnificus iron-uptake systems. These iron-uptake systems may be attractive candidates for the development of V. vulnificus vaccine. Iron-chelating therapy can also be a promising modality for the prevention and treatment of V. vulnificus infections.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bactérias
/
Vibrio
/
Infecção dos Ferimentos
/
Sepse
/
Vibrio vulnificus
/
Ferro
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS