Expression of Smad 2 and 3 on the Lesions of Leprosy / 대한피부과학회지
Korean Journal of Dermatology
; : 304-308, 2006.
Article
em Ko
| WPRIM
| ID: wpr-68604
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TT) and lepromatous leprosy (LL), that are characterized by strong cell-mediated immunity (CMI) and CMI anergy, respectively. Transforming growth factor-beta (TGF-beta) is a family of growth factors involved in essential physiological processes, including development, differentiation, tissue repair, cell growth control and inflammation. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface receptors that activate transcription factors of the Smad family. Deregulation of the TGF-beta-Smad signaling pathway has been implicated in developmental disorders and several human diseases. Recently, ELISA & immunohistochemistry revealed high expression of TGF-beta isoforms in LL. OBJECTIVE: The purpose of this study was to investigate TGF-beta-Smad signaling in various forms of leprosy. METHODS: We investigated the involvement of TGF-beta by immunohistochemical staining for Smad 2 and 3 in skin biopsies from six patients of BL and four patients of TT. RESULTS: The inflammatory cells, keratinocytes and fibroblasts in BL showed strong positivity for both Smad 2 and 3, whereas those in TT showed little positivity. CONCLUSION: The high expression of Smad 2/3 in BL could represent high expression of TGF-beta, which possibly contributes to local CMI anergy and other clinical characteristic features of leprosy.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Pele
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Fatores de Transcrição
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Biópsia
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Ensaio de Imunoadsorção Enzimática
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Imuno-Histoquímica
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Hanseníase Virchowiana
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Hanseníase Tuberculoide
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Queratinócitos
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Doenças Transmissíveis
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Fator de Crescimento Transformador beta
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Dermatology
Ano de publicação:
2006
Tipo de documento:
Article