Expression of Smad 2 and 3 on the Lesions of Leprosy / 대한피부과학회지
Korean Journal of Dermatology
;
: 304-308, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-68604
ABSTRACT
BACKGROUND:
Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TT) and lepromatous leprosy (LL), that are characterized by strong cell-mediated immunity (CMI) and CMI anergy, respectively. Transforming growth factor-beta (TGF-beta) is a family of growth factors involved in essential physiological processes, including development, differentiation, tissue repair, cell growth control and inflammation. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface receptors that activate transcription factors of the Smad family. Deregulation of the TGF-beta-Smad signaling pathway has been implicated in developmental disorders and several human diseases. Recently, ELISA & immunohistochemistry revealed high expression of TGF-beta isoforms in LL.OBJECTIVE:
The purpose of this study was to investigate TGF-beta-Smad signaling in various forms of leprosy.METHODS:
We investigated the involvement of TGF-beta by immunohistochemical staining for Smad 2 and 3 in skin biopsies from six patients of BL and four patients of TT.RESULTS:
The inflammatory cells, keratinocytes and fibroblasts in BL showed strong positivity for both Smad 2 and 3, whereas those in TT showed little positivity.CONCLUSION:
The high expression of Smad 2/3 in BL could represent high expression of TGF-beta, which possibly contributes to local CMI anergy and other clinical characteristic features of leprosy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Fatores de Transcrição
/
Biópsia
/
Ensaio de Imunoadsorção Enzimática
/
Imuno-Histoquímica
/
Hanseníase Virchowiana
/
Hanseníase Tuberculoide
/
Queratinócitos
/
Doenças Transmissíveis
/
Fator de Crescimento Transformador beta
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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