Expression of Inhibin in the Whole-body gamma-irradiated Mouse Ovary / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 35-44, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-68615
ABSTRACT
OBJECTIVE:
The purposes of the present study were to investigate the effect of gamma-radiation on the expression of inhibin-alpha proteins and genes for inhibin alpha, betaA, and betain the ovary.METHODS:
Immature mice were whole-body gamma-irradiated with 25% of a lethal dose. At time 0, 3, 6, 12, and 24 hours after the irradiation,the ovaries were collected and used for immunohistochemistry for inhibin-alpha, and RT_PCR for inhibin-alpha, betaA, and betaB.RESULTS:
The expression of the immunoreactive inhibins-alpha was maintained at 12 hours post-irradiation and reduced thereafter. The expression of inhibin-alpha mRNA was significantly increased with the time after the irradiation. However there were no significant changes in the expression of betaA and betaB mRNAs.CONCLUSION:
It might be thought that inhibin acts as one of the regulatory factors in the gamma-radiation-induced follicular atresia in mice
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ovário
/
RNA Mensageiro
/
Imuno-Histoquímica
/
Atresia Folicular
/
Inibinas
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Fertility and Sterility
Ano de publicação:
2006
Tipo de documento:
Artigo
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