Effect of levetiracetam on electrical status epilepticus during sleep in benign childhood epilepsy with centro-temporal spikes / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 34-36,40, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-686508
ABSTRACT
Objective To investigate the effect of levetiracetam on benign childhood epilepsy with centro-temporal spikes(BECT) with early-electrical status epilepticus during sleep(ESES).Methods Since June 2010 to June 2013,35 cases of BECT with ESES were treated in our hospital.They were divided into two groupsearly-ESES group and ESES group.The seizure rate and spike-wave index in different groups were observed before and after treatment.Intelligence quotient(IQ),response control quotient,attention quotient in different groups were compared before and after treatment.Results The seizure-free rate in earlyESES group was 55.00%,the total effective rate was 85.00%,EEG improvement rate was 60.00%.The seizure-free rate in ESES group was 26.67%,the total effective rate was 73.33%,EEG improvement rate was 46.67%.The seizure-free rate,total effective rate and EEG improvement rate in early-ESES group were higher than that in ESES group,but there were no statistically significant differences between two groups.The cognitive function (verbal IQ90.29 ± 13.47 vs.83.97 ± 10.20; performance IQ93.83 ± 11.12 vs.87.03 ± 11.15; full IQ94.26 ± 10.96 vs.86.71 ± 11.29) and visual attention in both groups (response control quotient100.77 ± 7.91 vs.87.40 ± 9.68 ; attention quotient94.66 ± 7.22 vs.79.46 ± 12.52) were significantly improved after treatment(P < 0.05,respectively).Conclusion Levetiracetarn is effective on BECT with ESES and early-ESES,especially on early-ESES.Levetiracetam maybe have a preventive effect on ESES.
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pediatric Emergency Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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