Molecular mechanisms of anti-inflammatory action of AMPK / 生理学报
Acta Physiologica Sinica
; (6): 329-334, 2018.
Article
em Zh
| WPRIM
| ID: wpr-687821
Biblioteca responsável:
WPRO
ABSTRACT
AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, is known as the "cellular energy regulator" and a key molecule to maintain the energy balance of cells and organism. Recent studies have shown that AMPK exerts anti-inflammatory effects mainly through activating SIRT1, PGC-1α, p53, FoxO3a and p300, and down-regulating the activity of various inflammatory related proteins such as NF-κB and AP-1. This article reviews the molecular mechanisms of the anti- inflammatory effects of AMPK, and provides some clues for the development of AMPK-targeted therapeutics to treat inflammation and related diseases.
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1
Índice:
WPRIM
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2018
Tipo de documento:
Article