Polymorphisms of MICA gene and their linkage disequilibrium with HLA-B among ethnic Han Chinese from Shenzhen / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 747-752, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-688152
ABSTRACT
<p><b>OBJECTIVE</b>To study the distribution of MICA alleles among ethnic Han Chinese blood donors from Shenzhen and their linkage disequilibrium with HLA-B gene.</p><p><b>METHODS</b>For 143 randomly selected blood donors, the MICA and HLA-B alleles were determined with a PCR-sequence based typing (SBT) method. Allelic frequency, haplotypic diversity and linkage disequilibrium were analyzed with a Pypop software.</p><p><b>RESULTS</b>Thirteen MICA and 35 HLA-B alleles were identified among the 143 blood donors, among which MICA*00801 had the highest frequency (76/286), whilst MICA*00801-HLA-B*4001 and MICA*010-HLA-B*4601 were the most common haplotypes. No novel allele was identified.</p><p><b>CONCLUSION</b>The allele frequencies, haplotype diversities and linkage disequilibrium parameters under a high resolution can facilitate further studies and applications of the MICA and HLA-B genes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2018
Tipo de documento:
Artigo
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