Research advances in the role of aptamers in the diagnosis and targeted therapy of pediatric cancer / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 421-427, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-689614
ABSTRACT
Aptamers are single-stranded DNA or RNA which are isolated from synthesized random oligonucleotide library in vitro via systematic evolution of ligands by exponential enrichment (SELEX) and can bind to metal ions, small molecules, carbohydrates, lipids, proteins, and others targets with high affinity and specificity. Aptamers have the advantages of simple preparation, good thermal stability, and low immunogenicity and have great potential in the medical fields such as molecular imaging, biosensing, early diagnosis of diseases, and targeted therapy. Aptamer technology may be useful for early diagnosis and targeted therapy of pediatric cancer, and may avoid the side effects of conventional chemotherapy, such as growth and development disorders and long-term organ dysfunction. This article reviews the latest research advances in the selection and application of aptamers for pediatric cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Diagnóstico
/
Tratamento Farmacológico
/
Técnica de Seleção de Aptâmeros
/
Detecção Precoce de Câncer
/
Terapia de Alvo Molecular
/
Métodos
/
Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Criança
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2018
Tipo de documento:
Artigo
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