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Identification of mouse brain neuropeptides by high throughput mass spectrometry / 生物工程学报
Chinese Journal of Biotechnology ; (12): 594-601, 2018.
Article em Zh | WPRIM | ID: wpr-690144
Biblioteca responsável: WPRO
ABSTRACT
Neuropeptides play an important role in the physiological functions of the human body. The physiological activities such as pain, sleep, mood, learning and memory are affected by neuropeptides. Neuropeptides mainly exist in the nerve tissue of the body, and a small amount of them are distributed in body fluid and organs. At present, analysis of large-scale identification of neuropeptides in whole brain tissue is still challenging. Therefore, high-throughput detection of these neuropeptides is greatly significant to understand the composition and function of neuropeptides. In this study, 1 830 endogenous peptides and 99 novel putative neuropeptides were identified by extraction of endogenous peptides from whole brain tissue of mice by liquid phase tandem mass spectrometry (LC-MS / MS). The identification of these endogenous peptides provides not only a reference value in the treatment and mechanism studies of diseases and the development of drugs, but also the basis for the study of a new neuropeptides and their functions.
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Texto completo: 1 Índice: WPRIM Tipo de estudo: Diagnostic_studies Idioma: Zh Revista: Chinese Journal of Biotechnology Ano de publicação: 2018 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Tipo de estudo: Diagnostic_studies Idioma: Zh Revista: Chinese Journal of Biotechnology Ano de publicação: 2018 Tipo de documento: Article