MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 467-472, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-690633
ABSTRACT
There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protection of mice from total body radiation (TBI), and the underlying protective mechanisms. Ilomastat treatment increased the survival of mice after TBI. Ilomastat pretreatment promoted recovery of hematological and immunological cells in mice after 6 Gy γ-ray TBI. Our findings suggest the potential of ilomastat to protect against or mitigate the effects of radiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Efeitos da Radiação
/
Lesões Experimentais por Radiação
/
Protetores contra Radiação
/
Baço
/
Sangue
/
Células Sanguíneas
/
Análise de Sobrevida
/
Irradiação Corporal Total
/
Usos Terapêuticos
/
Relação Dose-Resposta a Droga
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2018
Tipo de documento:
Artigo
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