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Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties / 中西医结合学报
Journal of Integrative Medicine ; (12): 147-152, 2018.
Artigo em Inglês | WPRIM | ID: wpr-691079
ABSTRACT
This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex species. The compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Flavonoides / Extratos Vegetais / Química / Vitex / Tratamento Farmacológico / Inflamação / Anti-Inflamatórios / Neoplasias Limite: Animais / Humanos Idioma: Inglês Revista: Journal of Integrative Medicine Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Flavonoides / Extratos Vegetais / Química / Vitex / Tratamento Farmacológico / Inflamação / Anti-Inflamatórios / Neoplasias Limite: Animais / Humanos Idioma: Inglês Revista: Journal of Integrative Medicine Ano de publicação: 2018 Tipo de documento: Artigo