Role of tumor-associated myeloid cells in the formation of immune microenvironment in multiple myeloma / 白血病·淋巴瘤

ABSTRACT

Although great progress has been made in the treatment of multiple myeloma (MM), it is still an incurable malignant plasma cell tumor. In addition to the MM cell itself, the bone marrow microenvironment also plays a critically important role to prompt MM cell's survival, growth, and drug resistance. Bone microenvironment reformed by MM cells could not only help the proliferation of MM cells, but also inhibit the killing of the immune system to MM. A variety of cell components and mechanisms participate in the formation of immune microenvironment, including high-profile tumor associated myeloid cells (TAMC). This paper introduces the mechanisms of TAMC in MM immunosuppressive microenvironment.