Study on correlation between serum γ-glutamyltransferase and hypertension / 重庆医学

ABSTRACT

Objective To investigate the correlation between serum γ-glutamyltransferase(γ-GGT) and hypertension onset.Methods A total of 1 487 subjects without hypertension undergoing physical examination in the hospital during 2016 were selected as the study subjects and equally divided into 2 groups according to γ-GGT level.The hypertension onset situation in 2011 was observed after 5-year follow up.The levels of serum γ-GGT,AST,triacylglycerol,total cholesterol,high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),fasting blood glucose and anthropometry indexes were measured in the study subjects.Results The 5-year follow up found that the incidence rate of hypertension in the high γ-GGT group was higher than that in the lowγ-GGT group,the difference was statistically significant(P＜0.05).After correcting various metabolic indexes of sex and base line,the γ-GGT change value had a correlation with the hypertension incidence rate[RR =1.012,95 ％ CI(1.004,1.019)],after correcting the 5-year change value of sex and various metabolic indexes,RR of γ-GGT change value causing hypertension onset =1.013,95％CI(1.005,1.020),the difference was statistically significant(P＜0.05).Conclusion γ-GGT is closely correlated with prehypertension.