Differences in clinical manifestations and prognosis between adult and child anaphylactoid purpura / 重庆医学

ABSTRACT

Objective To investigate the differences in clinical manifestations and prognosis between adult and child Henoch-Schonlein purpura(HSP).Methods The data in 320 cases of HSP in Zhengzhou Municipal Children′s Hospital and First Affiliated Hospital of Zhengzhou University from November 2013 to December 2016 were retrospectively analyzed.Then the differences in clinical manifestations and prognosis between adult and child HSP were compared.Results Purpura was mainly distributed in double lower limbs,but the proportion of double upper extremities distribution in adults was higher than that in children(43.8%vs.20.1%).Child HSP was easier to appear the joint symptoms than adult HSP(55.4% vs.26.0%),adult HSP was easier to ap-pear diarrhea(20% vs.1.6%);adult HSP was easier to appear serum IgA level increase and anemia(26.3% vs.3.5%,25% vs. 7.1%).Renal injury in adult HSP was more severe than that in children(78.1% vs.29.0%);the 31-month follow up found that the proportion of adult HSP progressing to chronic renal insufficiency was 9.4%,which in child HSP was 1.3%.Conclusion The great differences in the HSP clinical manifestations exist between adult and child HSP.Adult HSP is easier to appear renal involve-ment and its prognosis is poorer.