Expression and significance of CXCL12, CXCR4, MVD in MM bone marrow micro niche / 重庆医学
Chongqing Medicine
;
(36): 1733-1736, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-692011
ABSTRACT
Objective To study expression,distribution,significance and relationship of CXCL12,CXCR4,microvessel density (MVD) in multiple myeloma (MM) bone marrow micro niche.Methods 63 cases of patients with MM were chosen as the experimental group,42 cases of healthy persons were chosen as the control group.The expression and distribution of CXCL12,CXCR4,MVD were detected by immunohistochemical method.Results Compared with the control group,the expressions of CXCL12,CXCR4,MVD in the experimental group were higher,the difference was statistically significant (P < 0.05),their expressions in bone marrow were not significantly different from gender,age,immunoglobulin type and light chain classification (P>0.05);the expression of CXCR4,MVD were positively related with CXCL12 (P<0.05).Conclusion The expression of CXCL12,CXCR4,MVD may be related to the occurrence of MM;CXCL12/CXCR4 biological axis could promote the angiogenesis of MM bone marrow micro niche.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chongqing Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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