Effect of Budesonide combined with clarithromycin on chronic rhinosinusitisandits mucosa remodeling / 中国耳鼻咽喉头颈外科

ABSTRACT

OBJECTIVE To explore the application of Budesonide combined with clarithromycin in the treatment of patients with chronic rhinosinusitis(CRS) and observe the effect on mucosa tissue remodeling.METHODS 90 cases of CRS patients were selected in our hospital.They were randomly divided into Budesonide treatment group,clarithromycin treatment group and the two combined treatment group.VAS score,sinus CT Score were compared among the three groups before and after treatment.Airway remodeling and the occurrence of adverse reactions were also compared among the three groups.RESULTS After treatment,VAS score and Sinus CT scoreof the combined treatment groupwere significantly better than that of the other two groups(P＜0.05);Airway damage in combined treatment group was also lighter,basement membrane thickening was not obvious.The gray value of TGF-β1 in the combined treatment group was significantly higher than that of the other two groups(P＜0.05);Drug adverse reaction occurred less and resolved after treatment.CONCLUSION Budesonidc combined with clarithromycin can significantly improve the state of illness in patients with CRS and alleviate mucosal tissue remodeling.It is worthy of recommendation in clinical practice.