Molecularly Imprinted Polymer Electrochemical Sensor Based on Fe3O4/MnO2 Doped Graphene Composites for Determination of 17β-Estradiol in Aquatic Environment / 分析化学

ABSTRACT

In this paper, Fe3O4/MnO2doped graphene molecularly imprinted hybrid material ( Fe3O4/MnO2-MIP@ RGO ) was successfully synthesized via reversible addition fragmentation chain transfer ( RAFT ) molecularly imprinting technique by using methacrylic acid as functional monomer, divinylbenzene as cross-linker, Fe3O4/MnO2@ RGO as carrier, and 17β-estradiol ( 17β-E2 ) as template molecule. A novel molecularly imprinting electrochemical sensor by using Fe3O4/MnO2-MIP@ RGO modified electrode was constructed to specifically detect trace 17β-E2 in water. The experimental results showed that the Fe3O4/MnO2-MIP@ RGO electrochemical sensor exhibited rapid and linear current response to 17β-E2 in water samples with a linear range of 4 nmol/L to 0. 8 μmol/L ( R=0. 9852) , the detection limit was 47. 2 pmol/L (3σ) and the relative standard deviation (RSD) was from 2. 1% to 2. 5% . This study provides a simple and efficient, economical and reliable method for the monitoring of 17β-estradiol in the complex water environment.