Cellular senescence and cancer progression / 国际儿科学杂志

ABSTRACT

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation.However,accumulating evidence show that senescent cells can have deleterious effects on the tissue microenvironment.The most significance of these effects is the acquisition of a senescenceassociated secretory phenotype (SASP) that could promote tumor progression.Even with our currently limited knowledge of the SASP and its potential effects on carcinogenesis,promising new strategies for cancer therapies are possible.