Research status of congenital renal and urinary tract malformation in children / 国际儿科学杂志

ABSTRACT

Congenital abnormalities of the kidney and urinary tract (CAKUT)is caused by a variety of reasons,with various phenotypes characterized by congenital anatomic abnormalities of urinary system,and the rate of occurrence is nigh.CAKUT is the main cause of chronic kidney disease in cnildren,and some patients can progress to end-stage renal disease(ESRD).The study of CAKUT in cnildren is of great significance to eugenics,and its pathogenesis is not completely clear.However,many studies have proved that the pathogenesis of CAKUT is related to many factors,such as gene mutation,copy number variation and environment.In addition,the use of color doppler ultrasonography has a significant advantage in the discovery of cnildren's CAKUT.It is the first choice for screening,and then the early corresponding treatment intervention will greatly reduce the degree of damage to the renal function of the cnildren and improve the survival rate of the cnildren,which is of great significance for the prevention of disease.We reviewed the epidemiological studies,etiological studies,color doppler ultrasound screening and interventive treatment of children with CAKUT in recent years,in order to make pediatricians understand children's CAKUT more comprehensively,and take active intervention measures to delay the progress of CKD and orevent the occurrence of ESRD.