Progresses of pericytes in central nervous system microvascular diseases / 国际儿科学杂志

ABSTRACT

Pericyte is a type of important cellular constituents in the central nervous system (CNS),which is located at periphery of the microvessel wall,surrounded by basement membrane (BM) and connected with endothelial cell (EC) and astrocytes endfeet.As such important components of microvasculature,diverse functions have been assigned to pericytes,including control of brain blood flow,development and maintenance of the blood-brain barrier,regulation of the neuroinflammation and may function as pluripotent stem cells.The dysfunction of brain pericytes is associated with the progression of many CNS diseases.The occurrence of the disease leads to pericytes injury.The dysfunction of the brain pericytes make the disease worse.Increasing evidence suggests a highly specialized role for pericytes in a wide range of CNS diseases like Alzheimer's disease,stroke,subarachnoid hemorrhage,epilepsy and so on.