Advances in Shh signaling pathway of renal interstitial fibrosis / 国际儿科学杂志

ABSTRACT

Sonic hedgehog signaling pathway has a unique role in the process of renal fibrosis,while it is mainly expressed in the impaired renal tubular epithelial cells. Shh signaling pathway promotes the process of epithelial-mesenchymal transition and renal tubulointerstitial fibrosis. Shh signaling pathway ligand triggers cell proliferation in the pericyte,suggesting a possible role for this pathway in the regulation of cell cycle progression of myofibroblasts progenitors during the development of renal fibrosis. Shh protein can be expressed at the early stage of kidney injury,which indicates that Shh signaling pathway is involved in the tissue repair process after kidney injury at the early stage. The process of renal interstitial fibrosis related to signaling pathway is involved with signaling pathway and proteins,cytokines,extracellular matrix,complement and so on. This paper reviews the progress in the study of the relationship between Shh and renal interstitial fibrosis.