Evaluation of Logistic regression and ROC curve on diagnostic value of serum WBC, CRP,D-D and FIB in mycoplasma pneumoniae infection / 国际检验医学杂志

ABSTRACT

Objective To analyze the correlation among WBC,CRP,D-D,FIB in the patients with myco-plasma pneumonia,and to evaluate the application values of single and combined detection of various indicators for screening mycoplasma pneumoniae(MP)infection by using the Logistic regression and receiver operating characteristic(ROC)curve.Methods A total of 473 patients with MP-DNA detection in the Affiliated Shang-dong Provincial Hospital of Shandong University from March 2015 to March 2017 were collected.The levels of WBC,CRP,D-D and FIB were compared among these cases.The cases were divided into the positive group(87 cases)and negative group(386 cases)according to the results of MP-DNA detection.Contemporaneous 100 subjects undergoing healthy physical examination were selected as the control group.The Logistic regression model was used to make ROC curve and the area under the ROC curve was calculated to evaluate the diagnos-tic value of each indicator.Results The levels of WBC,CRP,D-D and FIB in the positive group were signifi-cantly higher than those in the control group,the difference was statistically significant(P<0.05).The best cutoff values under the ROC curve for various indicator were 8.51×109/L for WBC,4.94 mg/L for CRP, 1.135 mg/L for D-D and 3.39 g/L for FIB;the areas under the ROC curve of WBC,CRP,D-D and FIB were 0.708,0.743,0.735 and 0.748 respectively;the Youden index of joint detection was 0.502 and the sensitivity reached 97.0%.Conclusion The combined detection of WBC,CRP,D-D and FIB levels play the complementa-ry role in the differential diagnosis of MP infection,increases the Yourden index for diagnosing MP infection,and is conducive to clinical differential diagnosis and treatment.