Correlation analysis of immune function,coagulation function and pulmonary function in patients with pulmonary tuberculosis complicated with COPD / 国际检验医学杂志

ABSTRACT

Objective To investigate the changes of immune function and blood coagulation function in pa-tients with pulmonary tuberculosis(PTB)with chronic obstructive pulmonary disease(COPD)and its correla-tion with lung function.Methods 65 cases of PTB patients with COPD were selected as PTB with COPD group,50 cases of patients with PTB were selected as PTB group,another 50 healthy people were selected as control group;the level of immune function and coagulation function were compared between the three groups,and the relationship between immune function,coagulation function and pulmonary function was ana-lyzed.Results The differences of CD3+,CD4+,CD4+/CD8+,TT,APTT,PT,FIB,FEV1,FVC and MMEF between the three groups were statistically significant(P<0.05);The levels of CD3+,CD4+,CD4+/CD8+, APTT,FEV1,FVC and MMEF in PTB group and PTB group with COPD were significantly lower than those in control group,and PTB group with COPD group was significantly lower than that in PTB group,the differ-ence was statistically significant(P<0.05);The levels of TT and FIB in PTB group and PTB group with COPD were significantly higher than those in control group,and PTB group with COPD group was significant-ly higher than that in PTB group,the difference was statistically significant(P<0.05);The results of corre-lation analysis showed that FEV1,FVC and MMEF had significant positive correlation with CD3+,CD4+, CD4+/CD8+,APTT and PT(P<0.05),and negatively correlated with TT and FIB(P<0.05),and there was no significant correlation between FEV1,FVC,MMEF and CD8+(P>0.05).Conclusion The patients with PTB accompanied with COPD have abnormal cellular immune function and abnormal coagulation func-tion,and the level is significantly correlated with lung function.