The effects of early vitamin D supplementation on IL-2,IL-4 and immunoglobulin in premature infants with infectious diseases / 国际检验医学杂志

ABSTRACT

Objective To research the effects of early vitamin D supplementation on interleukin-2(IL-2), IL-4 and immunoglobulin in premature infants with infectious diseases.Methods A total of 66 patients with infectious diseases in our hospital were selected for this study.According to the random number table method, they were divided into the observation group(37 cases)and the control group(29 cases).Patients in the con-trol group were given conventional anti infection treatment while feeding powdered formulas,on this basis,pa-tients in the observation group were given vitamin D from the third day after birth.Compared the serum levels of 25-(OH)D,IL-2,IL-4 and immunoglobulin between the two groups during the treatment period.Results Before treatment,there were no significant differences in serum 25-(OH)D and IL-2,IL-4 levels between the two groups(P>0.05).After the treatment of 4 d and 12 d,the serum levels of 25-(OH)D and IL-2,in the ob-servation group were significantly higher than those in the control group,and the IL-4 was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in IgA,IgM and IgG levels between the two groups of preterm infants before treatment and after the treatment of 4 d and 12 d(P>0.05).At the same time,the premature infants in two groups also did not appear obvious adverse reactions during the treatment period,the clinical medication was safe and reliable. Conclusion For premature infants with infectious diseases,early vitamin D supplementation could effectively improve the levels of serum 25-(OH)D and IL-2,reduce the level of IL-4,so that the immune resistance has been significantly improved,to ensure the clinical efficacy of anti infective treatment is very favorable.The ear-ly vitamin D supplementation on the humoral immune globulin level has not been effectively confirmed.