Clinical diagnosis value of NEFA,ALB,BMG and CREA in patient with type 2 diabetic nephropathy / 国际检验医学杂志

ABSTRACT

Objective To investigate the clinical application value of serum non-esterified fatty acid(NE-FA),albumin(ALB),creatinine(CREA)and β2-microglobulin(BMG)levels in type 2 diabetic nephropathy (T2DN).Methods 140 cases of type 2 diabetes mellitus(T2DM)in this hospital from October 2016 to Febru-ary 2017 were selected and divided into the T2DM non-nephropathy group(47 cases)and T2DN group(93 ca-ses)according to urinary albumin and urinary microalbumin.The T2DN group was further divided into the ALB high value subgroup(ALB>30 g/L,47 cases)and ALB low value subgroup(ALB≤30 g/L,46 cases)ac-cording to serum ALB detection results.Meanwhile 51 persons undergoing healthy physical examination were selected as the healthy control group.The levels of NEFA,ALB,CREA and BMG were measured in each group.Then the correlation among groups was analyzed.Results The levels of serum NEFA and NEFA/ALB in the T2DM non-nephropathy group were significantly higher than those in the healthy control group,the difference was statistically significant(P<0.05).The serum NEFA level in the T2DN group was significantly higher than that in the healthy control group,and the levels of NEFA/ALB,BMG and CREA were higher than those in the healthy control group and T2DM non nephrotic group,while the ALB level was significantly lower than that in the healthy control group and T 2DM non nephropathy group,the difference was statistical-ly significant(P<0.05).The levels of BMG and CREA in the ALB high value subgroup and ALB low value subgroup were significantly higher than those in the T 2DM non-nephropathy group ,the difference was statisticallysignificant( P < 0 .05) ;the levels of NEFA and ALB in the ALB low value subgroup were significantlylower than those in the T2DM non-nephropathy group and ALB high value subgroup ,while the NEFA/ALBlevels were significantly higher than those in the T2DM non-nephropathy group ,the difference was statisticallysignificant(P < 0 .05) .The ALB was positively correlated with NEFA level (r = 0 .252 ,P < 0 .01) ,and wasnegatively correlated with BMG and CREA levels (r = - 0 .424 ,r = - 0 .281 ,P < 0 .01) ;serum BMG level waspositively correlated with serum CREA level (r = 0 .920 ,P < 0 .01 ) .Conclusion Serum BMG ,CREA ,NEFAand ALB play an important role in progress of T2DN ,and can serve as the monitoring indicators of renal injury degree in T2DM .