Prognostic significance of D-dimer and fibrinogen degradation products in acute pulmonary embolism / 国际检验医学杂志

ABSTRACT

Objective To investigate the clinical significance of detecting the level of D-dimer and fibrino-gen degradation products(FDP)in the prognosis of acute pulmonary embolism(APE).Methods The plasma D-dimer and FDP levels in patients with APE were determined by the method of turbidimetric inhibition im-muno assay in 126 patients with respiratory medicine of Renmin Hospital of Wuhan University.According to the severity of APE patients,they were classified into high-risk group,middle risk group and Low-risk Group. According to the 6-month clinical outcome after treatment,the patients were divided into survival group and death group,and evaluate the predictive value of D-dimer and FDP levels in assessing the prognosis of patients with APE.Results With the increase in the severity of APE,the levels of D-dimer and FDP were significantly increased(P<0.05).The levels of D-dimer and FDP were significantly higher in the death group than those in the survivor group(P<0.05).The D-dimer and FDP level were positively correlated(r=0.437,P=0.000). ROC curve analysis showed that D-dimer>0.98 mg/L and FDP>10.02 mg/L had a higher prognostic value for APE Patients.Conclusion D-dimer and FDP levels are associated with the risk stratification and long-term prognosis of APE patients.Meanwhile,the combination of D-dimer and FDP can improve the accuracy of the disease severity and prognosis of APE patients,which deserves extensive attention in the new situation of clin-ical personalized medical care.