Analysis on the different expression of autontinuclear antibody in the patients with systemic lupus erythematosus between Uygur and Han / 国际检验医学杂志

ABSTRACT

Objective To explore the difference of serum autoantibody spectrum in patients with systemic lupus erythematosus (SLE).Methods ENA antibody in SLE patients was detected by immunoblotting,and anti nuclear antibody (ANA) was detected by indirect immunofluorescence (IIF),and the specific fluores-cence model was checked by microscope under fluorescence microscope.The results were statistically pro-cessed and evaluated.Results The positive rate of Ro-52(19.7%) and SSA (40.9%)in Han was higher than that in the Uygur,and the difference was statistically significant (7.5% and 30.0%,P<0.05).And the positive rate of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA),proliferating cell nuclear antigen (PCNA) and histone in Han (20.0%,27.5%,42.5%,respectively) was lower than that in the Uygur (7.0%, 11.3% and 18.31%,P<0.01).There were significant differences in the expression of nucleosome and P-Prot antibody titers among different ethnic groups,the positive rate of nucleosome antibody in Uygur group (17.50%)was higher than that in Han group (11.27%,χ2=8.37,P<0.05).Compared with the Han group (18.31%),the P-Prot antibody was also increased in the Uygur group (42.50%,χ2=9.55,P<0.05).The positive rate of nucleosome antibody in Uygur patients with homogeneous positive samples was significantly higher than that in Han patients (χ2=10.43,P<0.01).Conclusion T he positive rates of anti-Ro-52,SSA,P-ANCA,PCNA and histone antibodies were different in patients with SLE,and there were significant differ-ences betweenin nucleosome and P-Prot antibody titer,which was of great significance in the diagnosis and the selection of the target for the treatment of SLE.