The diagnostic value of cerebrospinal fluid Cystatin C for optic neuritis / 国际检验医学杂志

ABSTRACT

Objective To evaluate the level of cystatin C (CysC) in cerebrospinal fluid of patients with optic neuritis and other neurological diseases .Methods Totally 46 patients with optic neuritis were selected ,and 86 patients in the control group ,including 26 cases of intracranial hypertension ,21 cases of ophthalmoplegia ,and 39 cases of other neurological diseases .The level of CysC in cerebrospinal fluid was measured by immunoturbi-dimetry ,and the myelin alkaline protease (MBP) level in cerebrospinal fluid of two groups was detected .The difference between cerebrospinal fluid synthesis rate and cerebrospinal fluid biochemical indexes was com-pared .Results The level of CysC in the cerebrospinal fluid of the patients with optic neuritis was significantly lower than that of the control group ,the difference was statistically significant (P<0 .05) .There was no sig-nificant difference in MBP and the ratio of cerebrospinal fluid synthesis in the two groups (P>0 .05) .The re-ceiver operating characteristic curve analysis showed that the area under the curve of CysC for the diagnosis of optic neuritis was 0 .640 .Conclusion CysC in cerebrospinal fluid is an indicator of the inflammatory state of the nervous system .The determination of CysC in cerebrospinal fluid is helpful for the diagnosis and identifi-cation of optic neuritis ,and it may be used to evaluate the curative effect and predict the prognosis of the dis-ease .