Management of Eosinophilic Granuloma Occurring in the Appendicular Skeleton in Children
Clinics in Orthopedic Surgery
;
: 63-67, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-69284
ABSTRACT
BACKGROUND:
We compared indomethacin therapy with the more aggressive approaches of anti-cancer chemotherapy and surgery in the treatment of isolated Langerhans cell histiocytosis (LCH) of bone in children.METHODS:
Comparisons were made with respect to healing of the lesion without recurrence, time to radiological healing of the lesion, time to functional recovery, and complications related to treatment.RESULTS:
Complete radiologic healing of the lesion (mean, 15.3 months) and functional recovery (mean, 5.6 months) were observed in all patients treated with either approach. No significant differences were noted in the time to complete radiologic healing or the time to functional recovery between the two groups. There were no recurrences with either approach until the last follow-up (mean, 56 months). Complications were common with anti-cancer chemotherapy, but indomethacin was well-tolerated.CONCLUSIONS:
Indomethacin seems to be effective for treating isolated LCH of bone in children. Hence, morbidities associated with aggressive treatment approaches such as anti-cancer chemotherapy or surgery can be avoided.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Doenças Ósseas
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Anti-Inflamatórios não Esteroides
/
Granuloma Eosinófilo
/
Indometacina
/
Inibidores de Ciclo-Oxigenase
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Clinics in Orthopedic Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
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