The value of combined detection of serum CEA ,CA125 and CA19-9 in the treatment of lung cancer patients / 国际检验医学杂志

ABSTRACT

Objective To evaluate the clinical value of serum carcinoembryonic antigen (CEA ) ,carbohy-drate antigens(CA)125 and CA19-9 in patients with lung cancer .Methods Eighty patients with lung cancer who were admitted to our hospital from 2010 to 2016 were selected ,57 cases of pulmonary benign lesion pa-tients were collected at the same period and 80 cases of healthy subjects with physical examination were select-ed as control .Serum CEA ,CA125 and CA19-9 levels were detected ,comparing the diagnostic value of 3 inde-xes separately and combined for lung cancer ,and analyzing the value of the combined detection of serum CEA , CA125 and CA19-9 in the evaluation of lung cancer .Results T he levels of serum CEA ,CA125 and CA19-9 in patients with lung cancer were significantly higher than those in benign lesion group and control group ,and data of the lung benign lesion group was higher than that of the control group ,and the difference was statisti-cally significant (P<0 .05) .The contents of CEA ,CA125 and CA19-9 increased gradually with the increase of TNM stage of lung cancer ,there were significant differences among stage Ⅰ ,Ⅱ and Ⅲ (P<0 .05) .The sensi-tivity of combined detection of the 3 indexes was significantly higher than those of separate detections (P<0 .05) ,but the specificity decreased ,the area under the receiver operating characteristic curve was significantly higher than that of the independent test .The effective rate of treatment in lung cancer group was 73 .75％(59/80) ,and the ineffective rate was 26 .25％ (21/80) .The average of CEA ,CA125 and CA19-9 in the effec-tive group was significantly lower than that in the ineffective group ,the difference was statistically significant (P<0 .05) .The serological results of the patients with different curative effects (complete remission ,partial remission ,stability and progression) showed that the levels of CEA ,CA125 and CA19-9 were statistically sig-nificant (P<0 .05) ,and the better the therapeutic effect ,the levels of CEA ,CA125 and CA19-9 in the patients were higher ,and there was a statistically significant difference between the groups (P<0 .05) .The follow-up results showed that the levels of CEA ,CA125 and CA19-9 in the recurrent group were significantly higher than those in the non recurrent group (P<0 .05) ,and the level of CEA ,CA125 and CA19-9 in the tumor me-tastasis group was significantly higher than that in the non metastatic group (P<0 .05) .In the end ,55 cases were included in the 5 year survival rate ,and the survival rate was 38 .18％ (21/55) .The serum CEA ,CA125 and CA19-9 levels in the survival group were significantly lower than those in the death group ,the difference was statistically significant (P<0 .05) .Conclusion Combined detection of serum CEA ,CA125 and CA19-9 can effectively diagnose lung cancer ,and has important application value for clinical efficacy ,recurrence and metastasis assessment .