Association between TNFα-308 polymorphism and inflammatony bowel disease susceptibility in Chinese people: A Meta-analysis / 国际外科学杂志

ABSTRACT

Objective To evaluate the association between TNFα-308 polymorphism and inflammatory bowel disease susceptibility in Chinese people.Methods The literatures about the association between TNFα-308 polymorphism and inflammatory bowel disease were collected by searching related database until July 2017.The theme words included "TNFα gene polymorphism inflammatory bowel disease" and "the free words" included "single nucleotide polymorphism nucleic acid polymorphism ulcerative colitis Crohn's disease nonspecific enteritis" were used for searching,then x2 wasapplied test to determine the combined effect heterogeneity and then analyzed the relationship between TNFα-308 polymorphism and inflammatory bowel disease disease through recessive and dominant model.Results A total of 6 references met inclusion criteria,and there were 536 patients in the case group (patients with inflammatory bowel disease) and 927 patients in the control group (normal people) healthy controls were included in this study.Recessive model OR =0.86 (95％ CI:0.30-2.46,x2 =3.02,P ＞ 0.05),Dominant model OR =1.32(95％ CI:0.95-1.84,x2 =21.58,P ＜ 0.05),After heterogeneity analysis and sensitivity test,the original research with more influence was excluded,and the final results with higher credibility were consistent with previous one.Conclusion Compared to A alleles,an individual who carries G alleles is more susceptible to ulcerative colitis,while Crohn's disease has no business with the polymorphism of TNFα.