Mechanism and clinical application of sodium-glucose co-transportor 2 inhibitors:research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 828-834, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-693321
ABSTRACT
Sodium-glucose co-transportor 2(SGLT2)exerts an important role in the reabsorption of renal glucose,and SGLT2 inhibitors could reduce the blood glucose level in type 2 diabetes mellitus patients by decreasing renal glucose reabsorption and in-creasing urine glucose excretion. This paper briefly reviews the renal regulation of glucose homeostasis and the regulatory mechanism of SGLT2 inhibitors,then summarized the administration,clinical pharmacology,adverse reaction and other aspect of clinical applica-tion of three most representive SGLT2 inhibitorsdapagliflozin,canagliflozin and empagliflozin,in hope of providing reference for clinical use of SGLT2 inhibitors in the future.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2017
Tipo de documento:
Artigo
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