The molecular mechanisms and potential drug targets to regulate neural stem cells migration / 国际药学研究杂志

ABSTRACT

At the moment,neural stem cells(NSC)therapy is one of the main means to improve stroke and neurodengenera?tive disease. This paper analyses the key molecular targets that promote NSC migration,such as chemokines,brain-derived neuro?trophic factor and vascular endothelial growth factor,and clarifies the relationships as well as important nodes between pathways,like PI3K/Akt,MAPK/ERK,and JAK/STAT.It is helpful to understand the molecular network mechanisms of NSC migration and provide ideas and targets to design creative drugs to promote NSC migration.