Effect of CCL19/CCR7 on the central nervous system function / 国际药学研究杂志

ABSTRACT

The chemokine CCL19 and its receptor CCR7 are widely expressed in the body by several types of cells,including neutrophils,macrophages and glial cells.The CCL19/CCR7 signaling pathway participates in the process of inflammation,homing of lymphocytes as well as the physiological function.Recently,more and more attention has been focused on the role of CCL19/CCR7 in the nervous system and related diseases such as multiple sclerosis and cerebral ischemia.However,the effect of CCL19/CCR7 on the central nervous system(CNS)is not clear.This paper reviews the relations of CCL19/CCR7 to the CNS,in hope of sheding light on the significance of CCL19/CCR7 for the nervous system.