Research advances of LINE-1 in tumor / 国际肿瘤学杂志

ABSTRACT

The abnormality of long interspersed nuclear element-1 (LINE-1) is closely related to the occurrence and development of tumor.Overexpression of LINE-1 can promote cell proliferation and affect the prognosis and metastasis of tumor.The retrotransposition and methylation status of LINE-1 have potential application value in clinical diagnosis,prognosis,disease monitoring and treatment.