Molecular mechanisms of castration-resistant prostate cancer progressed from prostate cancer by androgen deprivation treatment / 国际肿瘤学杂志

ABSTRACT

Androgen deprivation treatment (ADT) is the gold standard of care for patients with locally advanced or metastatic hormone-sensitive prostate cancer.However,most of these patients have developed to the castration-resistant prostate cancer (CRPC) after months or years through a series of different molecular mechanisms during ADT.So far,CRPC is still incurable and deadly,therefore,it is very important for researchers to study different molecular mechanism in the occurrence and development of CRPC,which may provide some new directions for targeted therapy.