Epithelial mesenchymal transition in airway remodeling of asthma and its molecular regulation / 中南大学学报(医学版)

ABSTRACT

Asthma is a chronic inflammatory disease of the airway.Repeated inflammatory injury and tissue repair can lead to airway remodeling.The airway epithelial mesenchymal transformation (EMT) plays an important role in airway remodeling of asthma.Various cytokines and signaling pathways,such as transforming growth factor β (TGF-β),nuclear factor-kappa B (NF-κB) and bromodomain-containing protein 4 (BRD4),are involved in the molecular regulation of EMT.