Mitochondrial fusion-fission and heart failure / 基础医学与临床
Basic & Clinical Medicine
;
(12): 553-556, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-693939
ABSTRACT
Mitochondrial fusion,fission and dynamic transformation between the two are commonly known as mito-chondrial dynamics. Mitochondrial fusion-fission is related to a variety of biological functions of mitochondria inclu-ding regulation of energy metabolism, production of reactive oxygen species, maintenance of Ca2+homeostasis and influence of cellular death. Cardiac development,energy metabolism and ion homeostasis are closely related to the balance of mitochondrial fusion-fission.Mitochondrial fusion-fission disorders may cause myocardial cell dysfunction, damage and even the death of myocardial cells,which result in heart failure ultimately. Developing medicines tar-getting to reconstruct the balance of mitochondrial fusion-fission may provide new ideas and strategies for the treat-ment of chronic heart failure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Basic & Clinical Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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