Effect of ACE/Ang Ⅱ/AT1 axis and ACE2/Ang(1-7)/Mas axis on glucose and lipid metabolism in adipose tissue / 基础医学与临床
Basic & Clinical Medicine
;
(12): 708-712, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-693969
ABSTRACT
The renin angiotensin system(RAS)includes two counterbalance axesthe ACE/Ang Ⅱ/AT1 axis and the ACE2/Ang(1-7)/Mas axis.The RAS can regulate glucose and lipid metabolism in adipose tissue.Most of evi-dences demonstrated that the ACE/Ang Ⅱ/AT1 axis can induce glucose metabolism disorders in adipose tissue, while ACE2/Ang(1-7)/Mas axis improves glucose metabolism.The RAS,which is over activated in obese patient, has been considered to be a potential link among obesity,dyslipidemia and insulin resistance.The effect of ACE/AngⅡ/AT1 axis and ACE2/Ang(1-7)/Mas axis on lipid and glucose metabolism in adipose tissue should be futh-er investigated,and we may find a new target for improving glucose and lipid metabolism.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Basic & Clinical Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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