Hormonal Therapy on Eunuchism and Eunuchoidism / 대한비뇨기과학회지

ABSTRACT

The writers, herein, report clinical findings and results of hormonal therapy applied on 10 eunuchs and 35 eunuchoids for the 10-year period from 1960 to 1969. The clinical findings of these subjects are summarized in the tables 1~4, and the results of the treatment, in table 5. Seven anorchisms in 10 eunuchs lost their testes and scrotum by dog bites and the remaining 3 cases, by industrial injuries. Ten cases of eunuchs and 8 cases of hypergonadotropic eunuchoids were given intramuscular injections of testosterone depot "MIRO-DEPO" (Hanil Pharm. Mfg. Co.), 100 mg every 10 days for 6~12 months. The remaining 27 cases of hypogonadotropic eunuchoids were administered injections of human chorionic gonadotropin "PUBEROGEN" (Tong-A Pharm. Mfg. Co. Tomoda Pharm. Mfg. Co.), 1,000 I.U. every 3 days combined with the testosterone depot, 100mg every 15 days, for 6 to 12 months. Improvements of male secondary sex characters such as sex hair growth, voice change, enlargement of penile size and masculine fat distribution were observed three to six months after the treatments. Such improvements were found in 90 per cent of eunuchs, 96 per cent of hypogonadotropic eunuchoids and 80 per cent of hypergonadotropic eunuchoids. Two of the hypogonadotropic eunuchoids were proved to become fertile (fertile eunuchoid) with long-term treatment of Puberogen.