Study on the short-term effect of intensive insulin therapy combined with ulinastatin in treatment of moderate to severe acute pancreatitis / 临床外科杂志

ABSTRACT

Objective To explore the clinical effect of intensive insulin therapy combined with ulinastatin in treatment of moderate to severe acute pancreatitis.Methods 70 patients were chosen due to sudden severe acute pancreatitis and received inpatient treatment,they were randomly divided into two groups(35 cases each)according to the different treatment,the control group received conventional treat-ment of acute pancreatitis combined with ulinastatin,combination group were based on the treatment of control group combined with intensive insulin therapy,analysing data between the two groups of patients in hospital time,,the third and seventh day of the APACHE-score before and after the treatment,white blood cells,red blood cell,platelet count,blood glucose,liver and kidney function,IL-6 and high sensitivity C-reactive protein(hs-CRP)changes.Results The time of hospitalization in the control group was(21.8 ± 13.2)days,the score of APACHE Ⅱ in the third day and seventh day were(10.5 ± 4.3)and(8.3 ± 3.1).The hospitalization time of the combined group was(18.9 ± 14.4)days and the third days,and the seventh days of APACHE Ⅱ score were(8.7 ± 3.2)and(5.7 ± 2.9)(P<0.05).The number of blood white blood cells,serum IL-6,hsCRP,alanine aminotransferase and serum creatinine between the two groups were also statistically significant after third and seventh days of admission(P<0.05).Conclusion Intensive insulin therapy combined with ulinastatin can significantly improve the short-term effect of in-patient treatment in patients with moderate to severe acute pancreatitis.