Phenotypic Characteristics of CD8(bright) T Cells in Behcet's Uveitis
Journal of the Korean Ophthalmological Society
;
: 1210-1216, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-69513
ABSTRACT
PURPOSE:
To determine the phenotypic characteristics of peripheral CD8(bright) T cells.METHODS:
Forty patients with Behcet's disease (BD) with uveitis (active 20; inactive 20) and 20 healthy controls were recruited in this study. Phenotypic analysis of fresh PBMCs was performed using anti-CD8 mAb and anti-CD56 mAb in conjunction with a three- or four-color immunofluorescence tests for the expression levels of the following molecules CD11b, CD27, CD45RA, CD45RO, CD62L, CD94, NKG2D, and HLA-DR.RESULTS:
CD27 and CD62L were down-regulated on peripheral CD8(bright) T cells in patients with active Behcet's uveitis in contrast to the up-regulation of CD11b and HLA-DR. These phenotypic natures were remarkable in the CD56+ subsets. CD45RA(dim)CD45RO- phenotypes were expanded in peripheral CD8(bright)CD56+ T cells according to the disease activity. Interestingly, in active Behcet's uveitis, CD94 was up-regulated on peripheral CD8(bright)CD56+ T cells in BD in contrast to the down-regulation of NKG2D compared with the normal controls.CONCLUSIONS:
CD8(bright)CD56+ T cells are characterized by activated effector phenotypes with functional NK receptors and they may play immunopathogenic roles in Behcet's uveitis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2005
Tipo de documento:
Artigo
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