Effects of GLP-1 analogues on kidney function and kidney ultrastructure in type 2 diabetic rats / 上海交通大学学报（医学版）

ABSTRACT

Objective·To study the effects of glucagon-like peptide-1 (GLP-1) analogues on kidney function and kidney ultrastructure in type 2 diabetic rats.Methods·Twenty-eight SPF level male SD rats were randomly divided into control groups (normal control group and diabetic control group) and GLP-1 analogues Exenatide intervention groups (normal intervention group and diabetic intervention group).The effects of Exenatide intervention on glucose,lipid metabolism,kidney function and kidney ultrastructure were observed.Results·Fasting glucose,fasting insulin,insulin sensitivity index,insulin resistance index,lipid profile,24-hours microalbuminuria,serum creatinine and blood urea nitrogen of Exenatide intervention group were much better than those of corresponding control groups.Through electron microscopy,glomerular mesangial cell in diabetic control group proliferated,basement membrane thickened,while glomerular mesangial cell in diabetic intervention group did not proliferate,basement membrane mildly thickened.Conclusion·GLP-1 analogues can improve kidney function of diabetic rats.Maybe it is connected with improving kidney ultrastructure.