Research progress of loco-regional therapy combined with immunotherapy for pancreatic ductal adenocarcinoma / 复旦学报（医学版）

ABSTRACT

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumor worldwide.Emerging evidence has shown that loco-regional therapy such as stereotactic body radiotherapy (SBRT) and radiofrequency ablation might be a rational choice for unresectable PDAC patients.Meanwhile,immunotherapy alone for PDAC have rarely achieved encouraging results.Accumulating data have revealed prominent tumor microenvironment change after loco-regional therapy in both target and remote lesions which might sensitize immunotherapy.It is thrilling to envisage the potential benefits of the combination therapy.We will focus on the underlining mechanism and clinical studies of the combination therapy.