Advances in designation of targeting nanocarrier-drug delivery systems for pancreatic cancer / 复旦学报（医学版）

ABSTRACT

Pancreatic ductal adenocarcinoma is a kind of neoplasms with poor neovascularization and rich matrix,which limited the delivery of cytotoxic drugs to cancer cells.Nanocarriers delivery of cytotoxic drugs to treat pancreatic cancer would overcome those biological barriers,and promote drug delivery efficiency.The designation of high targeting of pancreatic cancer cells nanoparticles and smart drug delivery system have been the key factors to improve nanocarriers' drug delivery efficiency.Here,we report the latest advanced researches in this field,including passive targeting design,active targeting design and response to the release of drug delivery design.