Study on Clinical Characteristics and Traditional Chinese Medicine Syndrome of Severe Pneumonia Associated Sepsis / 世界科学技术-中医药现代化

ABSTRACT

This study was aimed to investigate therapies in combination of traditional Chinese medicine (TCM) and western medicine from the investigation of clinical characteristics and TCM syndromes of patients with severe pneumonia associated sepsis in ICU.A retrospective study was conducted to collect clinical data on 113 patients suffered from severe pneumonia associated sepsis.The basic information on hospital admission,TCM syndrome of deficiency of excess,APACHE Ⅱ score,CD3+ (％),CD4+ (％),and CD8+ (％) were analyzed.The total days of hospitalization and treatment outcome were recorded.A total of 113 patients who met the diagnostic criteria of severe pneumonia associated sepsis were divided into the survival group and the death group.There were 81 patients in the survival group while 32 patients in the death group.The total mortality rate was 28.32％.There was a statistical difference between two groups on the days of hospitalization,APACHE Ⅱ score,CD3+ (％),CD4+ (％),CD8+ (％) and CD4+/CD8+ (all P ＜ 0.05).The days of hospitalization of the death group was longer than that of the survival group,with higher APACHE Ⅱ score (P ＜ 0.05).The survival group showed a higher level of CD3+ (％),CD4+ (％),CD4+/CD8+ (％) than that of the death group (P ＜ 0.05).The survival group showed a lower level of CD8+ (％) than that of the death group (P ＜ 0.05).The deficiency syndrome group showed a higher mortality rate than that of the excess syndrome group (P ＜ 0.05).APACHE Ⅱ score,the days of hospitalization,deficiency syndrome,and CD3+ (％) were related to the death outcome of sepsis patients.It was concluded that severe pneumonia associated sepsis predicates a higher mortality rate.The clinical data collected at the beginning of hospital admission shows a certain prediction effects to the disease prognosis.There is a certain correlation between TCM syndrome and the disease severity.The mortality rate of deficiency syndrome is higher.